Pyrroindomycins, novel antibiotics produced by Streptomyces rugosporus sp. LL-42D005. I. Isolation and structure determination.

نویسندگان

  • W Ding
  • D R Williams
  • P Northcote
  • M M Siegel
  • R Tsao
  • J Ashcroft
  • G O Morton
  • M Alluri
  • D Abbanat
  • W M Maiese
چکیده

Pyrroindomycins A and B were isolated from fermentations of culture LL-42D005, a strain of Streptomyces rugosporus. Pyrroindomycins possess potent antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci. Their structures have been determined by using 1- and 2-D NMR, mass spectroscopy and chemical degradations. Pyrroindomycins are the first natural products that contain the highly unsaturated pyrroloindole moiety.

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Pyrroindomycins, novel antibiotics produced by Streptomyces rugosporus LL-42D005. II. Biological activities.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 47 11  شماره 

صفحات  -

تاریخ انتشار 1994